SATuRN and BioAfrica open access reports:

Here we provide you with sections from our open access annual reports, which are directed at public health practitioners, policies makers, doctors, researchers and the general public.

The objective of these reports is to present the key aspects of our work in an accessible, summarized format. The majority of the work presented has been published in peer-reviewed publications and can be seen in the publications section of bioafrica.net.


Report Latest Reports

Deep sequencing shed light on low levels of PI resistance in patients with poor adherence

Authors: Gert van Zyl & Wolfgang Preiser

Cape Town, South Africa, 2012. A team from Division of Medical Virology, Stellenbosch University, University of Western Cape and University of California, San Diego performed deep sequencing and analysed results from 7 South African patients who failed a second-line lopinavir/ritonavir based regimen. Standard sequencing revealed no protease inhibitor (PI) resistance, but deep sequencing revealed low abundance PI resistant HIV variants in 5 of 7 patients, which probably does not emerge to become predominant due to inadequate drug pressure, in the setting of inadequate adherence.

This work may help to explain the higher probability of PI resistance in patients with intermediate to high levels of adherence. [Epublished in Journal of Virology, 28 March 2012]

Link: http://www.ncbi.nlm.nih.gov/pubmed/22457522

SATuRN's Featured Partner: The Division of Medical Virology, Stellenbosch University


SATuRN output, All reports...
SATuRN 2012 report - 2nd Nurses and Health Care Workers Drug Resistance Training for the scale-up of resistance testing in the Free State Province, South Africa
SATuRN 2012 report - SATuRN's Featured Partner: New TB centre at the London School of Hygiene and Tropical Medicine
SATuRN 2012 report - SATuRN's Featured Partner: Division of Medical Virology, Stellenbosh University
SATuRN output, All reports...


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