Deep sequencing shed light on low levels of PI resistance in patients with poor adherence
Authors: Gert van Zyl & Wolfgang Preiser
Cape Town, South Africa, 2012. A team from Division of Medical Virology, Stellenbosch University, University of Western Cape and University of California, San Diego performed deep sequencing and analysed results from 7 South African patients who failed a second-line lopinavir/ritonavir based regimen. Standard sequencing revealed no protease inhibitor (PI) resistance, but deep sequencing revealed low abundance PI resistant HIV variants in 5 of 7 patients, which probably does not emerge to become predominant due to inadequate drug pressure, in the setting of inadequate adherence.
This work may help to explain the higher probability of PI resistance in patients with intermediate to high levels of adherence. [Epublished in Journal of Virology, 28 March 2012]
SATuRN's Featured Partner: The Division of Medical Virology, Stellenbosch University
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