Tulio de Oliveira

My research interests concentrates on HIV evolution under selection pressure created in the transmission, acquisition and drug escape processes. A particular point of interest is on the study of the origins of HIV and the effect of network of transmissions in the spread of HIV in Africa and other continents. In addition, I am currently interested on the national implementation of SATuRN's drug resistance testing and clinical management system and on the usage of next generation DNA sequencing and bioinformatics for the study of the explosive HIV and TB epidemics in southern Africa.

Name: Tulio de Oliveira.

Email: tdeoliveira@africacentre.ac.za

Telephone: +27 35 550 7542

Research Summary

My research interests concentrates on HIV evolution under selection pressure created in the transmission, acquisition and drug escape processes. A particular point of interest is on the study of the origins of HIV and the effect of network of transmissions in the spread of HIV in Africa and other continents. In addition, I am currently interested on the national implementation of SATuRN's drug resistance testing and clinical management system and on the usage of next generation DNA sequencing and bioinformatics for the study of the explosive HIV and TB epidemics in southern Africa.

Background

Dr Tulio de Oliveira is a bioinformatician that has been working with HIV research since 1997. He has received his PhD at the Nelson R Mandela School of Medicine, UKZN, South Africa. He was a research fellow at the University of Oxford, U.K. from 2004 to 2006, where he received in depth training on virus genetic analysis and molecular evolution. He is recognized as an expert on HIV genetic data and bioinformatics and has published many high-impact articles including the one that proof the innocence of the six foreign medical personnel accused of infecting with HIV 438 children in a hospital in Libya (de Oliveira et al. Nature 2006), an open access and public HIV drug resistance databases in Africa (de Oliveira et al. Nature 2010) and the first case of proven HIV surrogate transmission in South Africa (Goedhals et al. Lancet 2012). He is currently a senior researcher at the Wellcome Trust-Africa Centre for Health and Population Studies, UKZN and the director of the Southern African Treatment Research Network (SATuRN).



Open access pdf Publications (last 10)

The tainted milk of human kindness.
Goedhals D, Rossouw I, Hallbauer U, Mamabolo M, de Oliveira T, Lancet (2012), 380:702.

WHO HIV drug resistance report 2012.
WHO ResNet, including - Jordan MR, Barcarolo J, Parkin N, de Oliveira T (analysis support), Bertagnolio S, WHO report (2012), ISBN 978 92 4 150393 8:.

Modeling HIV-1 Drug Resistance as Episodic Directional Selection.
Murrell B, de Oliveira T, Seebregts C, Kosakovsky-Pond SL, Scheffler K, on behalf SATuRN, PLoS Comput Biol (2012), 8(5):e1002507.

Primary drug resistance in South Africa - data from 10 years of surveys.
Manasa J, Katzenstein D, Cassol S, Newell ML, de Oliveira T, AIDS Res Hum Retroviruses (2012), 28(6):558-565.

Genetic Characteristics, Coreceptor Usage Potential and Evolution of Nigerian HIV-1 Subtype G and CRF02_AG Isolate.
Ajoge HO, Gordon ML, de Oliveira T, Green TN, Ibrahim S, Shittu OS, Olonitola SO, Ahmad AA, Ndung'u T, PLoS One (2011), 6(3):e17865.

Comparative performance of the REGA subtyping tool version 2 versus version 1.
Abecasis AB, Wang Y, Libin P, Imbrechts S, de Oliveira T, Camacho RJ, Vandamme AM, Infect Genet Evol. (2010), 10(3):380-5.

The HIV-1 Subtype C Epidemic in South America is Linked to the United Kingdom.
de Oliveira T, Pillay D, Gifford RJ; for the UK Collaborative Group on HIV Drug Resistance, PLoS One (2010), 19;5(2):e9311.

Public Database for HIV Drug Resistance in southern Africa.
de Oliveira T, Shafer WR, Seebregts C, for SATuRN, Nature (2010), 464(7289):673.

The RNA virus database.
Belshaw R, de Oliveira T, Markowitz S, Rambaut A, Nucleic Acids Res (2009), 37(Database issue):D431-5.

Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: high diversity of HIV genotypes.
Monteiro JP, Alcantara LC, de Oliveira T, Oliveira AM, Melo MA, Brites C, Galvao-Castro B, J Med Virol (2009), 81(3):391-9.

All publications...
Bioafrica Blogs from Bioafrica and SATuRN websitesBioafrica Blogs from Bioafrica and SATuRN websitesBioafrica Blogs from Bioafrica and SATuRN websitesBioafrica Blogs from Bioafrica and SATuRN websites
Blogs Blogs (last 5)

Bioafrica Blogs from Bioafrica and SATuRN websites

Zooming in on home-based health care givers in rural South Africa

Author: Lungani Ndwandwe, Tulio de Oliveira - 2012-09-13

ACiLT Practical Course on Quality Assurance of HIV-1 Drug Resistance Interpretation in Sequence Editing and Data Management Process, 7-11 May 2012

Author: Justen Manasa, Tulio de Oliveira - 2012-06-01

National Strategic Plan 2012-2016: Integrating research and all sectors of society to fight HIV, STIs and TB in South Africa

Author: Lungani Ndwandwe, Tulio de Oliveira - 2012-04-20

Shortage of doctors in rural South Africa?

Author: Lungani Ndwandwe, Tulio de Oliveira - 2012-03-29

Social Worker perspective: Adolescents on Antiretroviral (ARV) therapy - a VideoBlog

Author: Pretty Nkosi, Nokuthula Skhosana, Lungani Ndwandwe and Tulio de Oliveira - 2012-02-10

All blogs...
Bioafrica Reports from Bioafrica and SATuRN websitesBioafrica Reports from Bioafrica and SATuRN websitesBioafrica Reports from Bioafrica and SATuRN websitesBioafrica Reports from Bioafrica and SATuRN websites
Reports Reports (last 5)

Bioafrica Reports from Bioafrica and SATuRN websites

SATuRN's Featured Partner: New TB centre at the London School of Hygiene and Tropical Medicine

SATuRN 2012 report, date: 2012-07-03

Richard Lessells & Tulio de Oliveira

1st Nurses & Health Care Workers Drug Resistance Workshop

SATuRN 2012 report, date: 2012-06-01

Lungani Ndwandwe, Tulio de Oliveira

Transmited Drug Resistance data now more accessible through HIVDB GIS Tool

SATuRN 2012 report, date: 2012-03-29

Manasa J, Hunt G and de Oliveira T for SATuRN

A survey of 10 years of primary drug resistance in South Africa

SATuRN 2011 report, date: 2011-12-01

Manasa J, Cassol S, Seebregts C, Newell M-L, de Oliveira T

Phenotypic Resistance to Etravirine in an HIV-1 Subtype-C Background

SATuRN 2011 report, date: 2011-12-01

AE Basson, S-Y Rhee, CM Parry, T de Oliveira, D Pillay, R Shafer and L Morris

All reports...
Bioafrica HIV & TB Drug Resistance Clinical Cases TutorialBioafrica HIV & TB Drug Resistance Clinical Cases TutorialBioafrica HIV & TB Drug Resistance Clinical Cases TutorialBioafrica HIV & TB Drug Resistance Clinical Cases Tutorial
Clinical cases Clinical cases (last 5)

Bioafrica HIV & TB Drug Resistance Clinical Cases Tutorial

HIV Case 1 - Adult female with virological failure on first line d4T/3TC/EFV

Authors: Theresa Rossouw, Richard Lessells & Tulio de Oliveira

HIV Case 2 - Adult female patient with virological failure on first line therapy after substitution of EFV to NVP

Authors: Theresa Rossouw, Richard Lessells & Tulio de Oliveira

HIV Case 3 - Adult female patient on treatment for epilepsy with virological failure on TDF/3TC/EFV; previous single dose NVP for PMTCT

Authors: Richard Lessells, Theresa Rossouw & Tulio de Oliveira

HIV Case 4 - Adult female patient with virological and immunological failure after treatment interruption for symptomatic hyperlactataemia

Authors: Theresa Rossouw, Richard Lessells & Tulio de Oliveira

HIV Case 5 - Adolescent initiated on first line therapy of d4T/3TC/EFV with virological and immunological failure

Authors: Theresa Rossouw, Richard Lessells & Tulio de Oliveira

All cases...
Bioafrica News Section from Bioafrica and SATuRN websitesBioafrica News Section from Bioafrica and SATuRN websitesBioafrica News Section from Bioafrica and SATuRN websitesBioafrica News Section from Bioafrica and SATuRN websites
News News (last 5)

Bioafrica News Section from Bioafrica and SATuRN websites

Cape Argus

'Tainted milk' from wet nurse HIV risk

Cape Argus - 2012-08-26

By BIANCA CAPAZORIO - A BABY girl who contracted HIV after being breast-fed by a well-meaning aunt has become the first proven case in SA to have contracted HIV from a surrogate feeder or 'wet nurse'.


Zululand Observer

Local centre proves 'surrogate' HIV infection

Zululand Observer - 2012-08-24

The Africa Centre for Health and Population Studies, Zululand's HIV-AIDS research hub based near Mtubatuba, has revealed the first proven HIV surrogate transmission case in South Africa.


Wellcome Trust

DNA sequencing confirms HIV transmission through surrogate breastfeeding

Wellcome Trust - 2012-08-23

DNA sequencing has provided evidence of HIV-1 transmission from an infected woman breastfeeding her niece in South Africa, drawing attention to infant feeding practices and the need for HIV testing of all breastfeeding surrogates as well as mothers.


SABC

Breastfeeding in the spotlight

SABC - 2012-08-16

A case where an aunt infected her niece with HIV through breastfeeding has drawn attention to feeding practices in South Africa. The case was published in the medical journal Lancet and highlighted the risk of HIV transmission from a surrogate carer, the Africa Centre for Health and Population Studies said today.


GenomeWeb

Life Tech, SATuRN Collaborate on Dx for Antiretroviral Resistance in HIV in Africa

GenomeWeb - 2012-07-26

NEW YORK (GenomeWeb News) - Life Technologies today announced a collaboration with the Southern African Treatment and Resistance Network (SATuRN) covering sequencing-based diagnostics for HIV patients in Africa.


All news...