Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

265 patterns of major drug resistance mutations (defined here) from 53290 clinical isolates obtained from 48302 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2011-9-16). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Antimicrobial Agents and Chemotherapy, Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
DLV
foldn
EFV
foldn
None395400.74580.64440.6444
103N4541499327912092
181C12211234233421.242
103N,181C113840032225322933
100I,103N73069271902340027
188L619350165.71613016
181C,190A5602307207427
190A48891180.2186.018
103N,181C,190A365400325037003
103N,190A33850013712131
101E,181C,190A33335010211010310
101E,190A25645062.061206
101E1548.924.024.32
190S14419190.471049
106A13751384.08388
103S,190A12021832.02853
101P,103N113400320037003
103N,230L112600522543155
101E,190S10250051.554014
103N,188L102590234523852
106M987021323922
181I8540055252.05
103N,106M79   
101E,181C78400125014.01
181C,190S7726331233063
103N,106A6834948742784
190E6560055.657005
101E,181C,190S64   
181V5533228022.22
106A,190A5441710.91131
101P521742382382
101E,103N,190A48   
103N,188C45   
190Q4250048.145334
101E,103N41   
188C3721625823522
106M,190A35   
101P,190A34   
230L33252362142
103N,188H32378225014932
103N,190S29   
188H293.611217.31
103N,181I29   
236L282.015311.01
181C,188L28   
103S285.0110.012.41
188L,190A26   
101P,103S24350222525002
101E,188L2326315612381
106A,181C23   
100I,188L23   
103T21   
101E,103N,181C,190A21   
103N,106A,181C18   
181C,230L1769022062152
103N,181C,188C16   
106M,188L15   
103S,181C,190A14   
106A,181C,190A14   
101E,106M,190A14   
103H,181C,190A13   
106M,188C13   
103N,179F,181C13   
101P,188L12   
101E,106M12   
190C1228520.124352
100I113.1130110.01
100I,103N,181C11   
101E,181I11   
103N,179F,181C,190A11   
100I,103N,190A10   
106M,181C,190A10   
103N,106A,190A10   
101E,103N,181C10   
103N,181V9   
101E,190C9   
100I,103N,181C,190A9   
103S,106M9   
103N,181C,190S9   
103S,181C9   
100I,103N,181I9   
103N,106A,181C,190A8   
103N,181C,230L8   
106M,181C8   
103N,106M,181C8   
103N,236L7165119015.01
101E,188L,190A7   
106M,230L7   
101E,190V7   
190A,230L7   
181C,188L,190A6300112014001
101E,181I,190A6   
181C,188C6   
101P,181C6   
101E,181V,190A6400125017001
101E,179F,181C,190A5   
100I,103N,188H5   
103N,181C,188L5   
100I,103S5   
101E,188C5   
103N,106M,188C5   
101E,181V5   
100I,103N,230L4   
101E,181C,230L4   
179F,181C,190A4   
181C,236L4   
101E,106A,190A4   
103N,188C,190A4   
103N,106M,190A4   
103N,106M,181C,190A4   
101P,190S4   
181I,190A4   
101P,103N,190A4   
100I,230L4   
179F,181C,190S3   
188C,190A3   
190V360020.122702
103N,181V,190A3   
101E,106M,181C,190A3   
103N,190E3   
103N,181I,190A3   
100I,103N,106M3   
101E,106A,181C,190A3   
100I,101E,103N3   
103N,106M,230L3   
106M,188H3   
100I,103N,106A3   
101E,181I,188L,190A3   
179F,181C240012001211
106A,181C,188C2   
100I,181I2   
101E,106M,181V,190A2   
103T,236L2   
103N,181C,188H2   
101E,181V,190S2   
103T,230L2   
181C,190C2   
100I,181I,190A2   
188C,230L2   
100I,103N,188C2   
101E,190A,230L2   
100I,101E,181I,190A2   
103S,190S2   
101E,103N,188L2   
103S,188H,190A280017.418001
100I,181C2   
101E,181I,190S2   
103T,106A2   
103T,181C2   
100I,101E,190A2   
190T235610.111501
101E,190E2   
106A,190S2   
101E,103N,106A2   
181V,190A2   
181C,188C,190A2   
101E,103N,106A,181C,190A2   
100I,103N,188L2   
101E,103N,106M2   
101E,188H,190A2   
103N,188L,230L2   
106A,230L2