Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

39 patterns of major drug resistance mutations (defined here) from 4694 clinical isolates obtained from 4405 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2011-9-16). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Antimicrobial Agents and Chemotherapy, Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
None45291.683.282.51
140S,148H342007100034.11
155H332184541.81
143R13603  
143C10603  
92Q76.084262.01
148R632711830.81
138A,140S,148H5   
92Q,140S,148K,155H5   
143H4   
138K,147G,148R43421652 
66A3   
138K30.930.63 
138A3   
140S,148R31194 4.01
92Q,155H3120614622.41
140S,148H,155H2   
138K,140S,148H2   
140S22.034.03 
147G21.028.03 
140A,148R21501  
140S,143H,148H2