Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Grant Support
1. National Institute for Allergy and Infectious Diseases (NIAID, NIH): Online HIV Drug Resistance Database (PI: Robert W. Shafer, MD, 1R01AI68581-01A1), 04/01/06 - 3/31/11

2. National Institute for Allergy and Infectious Diseases (NIAID, NIH) supplement to the grant Identification of Multidrug-Resistant HIV-1 Isolates (PI: Robert W. Shafer, MD, AI46148-01): Supplement provided 1999-2005.

3. NIH/NIGMS Program Project on AIDS Structural Biology Program Project: Targeting Ensembles of Drug Resistant Protease Variants (PI: Celia Schiffer, PhD, University of Massachusetts): 2002-2007

4. University-wide AIDS Research Program (CR03-ST-524). Community collaborative award: Optimizing Clinical HIV Genotypic Resistance Interpretation: Principal Investigators: Robert W. Shafer, MD and W. Jeffrey Fessel MD (Kaiser Permanente Medical Care Program): 2004-2005

5. Stanford University Bio-X Interdisciplinary Initiative: HIV Gene Sequence Analysis for Drug Resistance Studies: A Pharmacogenetic Challenge Principal Investigators: Robert W. Shafer, MD and Daphne Koller, Ph.D. (Computer Science): 2000-2002

Industry and foundation support (Unrestricted educational grants)
Pharmaceutical companies

Abbott Laboratories (2000, 2002, 2004)
Agouron / Pfizer (1998, 2000)
Boehringer-Ingelheim (2002, 2004)
Bristol-Myers Squibb (2001, 2003, 2004, 2006)
Dupont Pharmaceuticals (2001)
Gilead Sciences (1998, 2001, 2004, 2006)
GlaxoSmithKline (1999, 2000, 2002, 2003, 2006)
Hoffman La Roche (1999, 2002, 2003, 2004, 2005, 2006)
Merck Pharmaceuticals (1998, 2000)
Triangle Pharmaceuticals (2002)
Diagnostic companies

Applied Biosystems, Inc (1998, 2000, 2001)
Celera (2003, 2005 - 2007)
Hoffman La Roche (1999, 2003, 2004)
Visible Genetics (1999)
Diagnostic laboratories

Laboratory Corporation of America (2003)
Nichols Institute (1999)
Specialty Laboratories (2000)
SRA Life Sciences (2000)
Medical education companies

Virology Networks (1999, 2004)
Academy of Continuing Education Programs (ACEP) (2000)
Non-profit organizations

J.M. Kaplan Foundation (2000)



Stanford Provost Statement (to the Faculty Senate) Supporting Expansion of HIVDB

"Earlier this year, Stanford Provost John Etchemendy asked the university's faculty Advisory Board to investigate an appeal brought to him by Professor Robert Shafer, a faculty member in the Department of Medicine. The Advisory Board concluded that that university made a mistake in not consulting with Professor Shafer before agreeing to a legal settlement involving the HIV database Web site created by Professor Shafer, an open and accessible resource used by clinicians and researchers worldwide studying treatments for HIV.

Provost Etchemendy agrees with the Advisory Board's conclusion. The provost determined that the university committed a serious procedural error when it did not consult with Professor Shafer prior to entering into an agreement with Advanced Biological Laboratories. In 2007, ABL threatened the university with litigation over alleged patent infringement by the HIV Web site. Although in settling with ABL, it was the intent of the university to protect Professor Shafer's valuable research and maintain broad access to the content of the Web site, it should not have done so without consulting and involving him in the process. The HIV Drug Resistance Database was started by Professor Shafer in 1998 and contains data contributed by medical researchers around the world. Funded by the NIH, multiple pharmaceutical and diagnostic companies, and Stanford, the database is used more than 100,00 times each month by clinicians and researchers--representing more than 100 countries--who are involved in HIV drug resistance testing and developing drugs to combat HIV.

Stanford University strongly supports the work done by Professor Shafer to develop the HIV database and affirms its ongoing value to the scientific community in diagnosing and treating HIV around the globe. The university wants to reassure scholars and scientists who have contributed content or provided financial support to the HIV database that Stanford endorses open access to the data. The HIV database represents the best of public service scholarship and research at the university, and as such, Provost Etchemendy will be providing further research funding in support of expansion of the database. Provost Etchemendy has apologized for the error before the university's Faculty Senate and has indicated that the university will establish a process to ensure that faculty members are consulted on legal settlements that directly impact their research. He has asked the Advisory Board to review university practices related to this issue and will recommend that Professor Shafer advise the Board on this issue."

June 13, 2010
John Etchemendy